Biotech startup looks to sidestep key problem with CAR-T cancer therapies
Tlisted below are two issues Phil Greenberg, the pinnacle of immunology at Fred Hutchinson Most cancers Analysis Heart, is very well-known for: a attribute wiry grey mop of hair and broad glasses, and a rock-solid status as one of many main researchers in most cancers immunotherapy.
Greenberg was behind among the key scientific advances that led to breakthrough CAR-T cell therapies, and co-founded Juno Therapeutics, a biotech that helped launch one of many first of these remedies. Now, he’s co-founding a brand new enterprise known as Affini-T Therapeutics, a Seattle and Massachusetts-based firm that hopes to remove cancers by concentrating on the supply of most cancers cells. The budding biotech, unveiled this week on the JPM Well being Care Convention, will use a comparatively new expertise generally known as engineered T-cell receptors, or TCRs, to focus on oncogenic driver mutations, errors in key genes that trigger cells to revolt and switch malignant within the first place.
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